RyanAir announced this week that they will cut the flight from Santiago de Compostela to Liverpool 27th of October.
They claim they will re-open the route in the spring, but nothing is confirmed.
It is thought that Ryanair might open a new route, to a new destination since Liverpool seems to be gone. No news of what destinations they are considering, but the rumors mentions Brussels or Milan as some of the possibilities.
More information in the article in La Voz de Galicia here