Here are transport options from Santiago to Lisboa.
I have not seen any schedule involving overnight buses or trains between these cities.
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Santiago to Porto and Lisboa
3301 This section describes transportation options from Santiago to Porto and Lisboa
Index 3300
3302 Planes
3302 Trains
3303 Buses
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Planes
There are flights from A Coruna to Lisboa.
A Coruña Airport (LCG)
http://www.aena-aeropuertos.es/csee/Satellite/Aeropuerto-A-Coruna/en/
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Trains
Renfe operates trains from Santiago to Vigo and from Vigo to Valenca.
CP Celta operates trains from Vigo to Porto.
CP operates regional and national trains from Valenca to Porto and Porto to Lisboa. Station Gare do Oriente is closest to Lisboa airport.
Renfe
http://www.renfe.com/
Comboios de Portugal (CP) (urban, regional, national, and international train services)
http://www.cp.pt/cp/displayPage.do?vgnextoid=87cbd5abe2a74010VgnVCM1000007b01a8c0RCRD
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Buses
Note: there is no central bus station in Porto.
Monbus provides bus service from Santiago bus station to Vigo bus station.
Autna provides bus service from Vigo bus station to Porto.
Autna has bus stops in Porto at the following locations from South to North:
a. Campo Mártires da Patria, 37
The closest Metro is Estação Sao Bento line D
b. Avda. de los Aliados – McDonald’s
The closest Metro is Estação Sao Bento line D
c. Aeropuerto
Metro line E
Renex operates buses from Porto to Lisboa.
Renex bus stop in Porto is located at Campo Mártires da Patria, 37. The closest Metro is Estação Sao Bento line D.
In Lisboa, Renex operates buses from Gare do Oriente which is co-located with the train station and is the closest station to the airport.
Rede Expressos operates buses from Porto to Lisboa.
Rede Expresso point of sale (and bus stop) in Porto is located Garagem Atlantico Rua Alexandre Herculano, 366 4000 Porto. The closest Metro is Estação Sao Bento line D.
In Lisboa, Rede Expressos operates buses from from Sete Rios bus station.
Monbus
http://www.monbus.es/index2.htm
Autna
http://www.autna.com/es/
Renex
http://www.renex.pt/
Rede Expressos
http://www.rede-expressos.pt/