travelling from Santiago to Villafranca del Bierzo

Santiago Compostela Villafranca Del Bierzo 08:00 11:40 3h 40min 18,61€
Santiago Compostela Villafranca Del Bierzo 09:45 13:40 3h 55min 18,61€
Santiago Compostela Villafranca Del Bierzo 21:30 01:05 +1day 3h 35min 18,61€
Santiago Compostela Villafranca Del Bierzo 23:15 02:05 +1day 2h 50min 18,61€

I would guess "No." The 2315 goes through Arzua, which would require passing the airport, but I do not know if the bus stops there.

SANTIAGO COMPOSTELA 23:15
ARZUA 23:40
MELLID/MELIDE 23:55
PALAS 00:05
MONTERROSO 00:15
LUGO 01:00
CHAMOSO 01:15
BARALLA. 01:25
BECERREA 01:35
NOGALES/NOGAIS 01:45
PIEDRAFITA DO CEBREIRO 01:55
AMBASMESTA 02:00
VILLAFRANCA DEL BIERZO 02:05

There are buses from the airport to Lugo, but the schedule does not seem to match your arrival time, departure time to Lugo, and departure from Lugo the Villafranca.