For prevention and to reduce friction over hot spots, I like Leukotape P, placed on the area after an application of Tincture of Benzoin, which increases the already strong adhesive holding power of the tape. There's no shifting, rolling up, or peeling away of the tape when combined with the benzoin.
For treatment and protection of a blister, I will first try using Leukotape P, applying an antibiotic ointment to the top skin on the blister -- to keep the tape from ripping of the skin when removed and to provide some sepsis control. This is done
after the blister has been slightly incised along its 'side' to prevent the fluid from re-collecting. Sometimes needle pokes re-seal. And don't get me started on the increased risk of infection that occurs when leaving even a sterilized thread, twine, floss, hemp rope, etc in the blister. Folks can do what they want with thread and I won't say a word... unless directly asked
Debates are not going to change one's firmly held beliefs.
For treatment of severely blistered areas where the underlying skin area is exposed, I have taken a liking to Spenco 2nd Skin Aquaheal Hydrogel Bandages. It has some therapeutic similarities to Compeed, but for wound care I like the Spenco product better. If Hydrogel is not available, substitute with Compeed.
When treating someone with an area where the blistered skin has peeled off, I will trim away any remaining flap of skin, then apply an antibiotic ointment directly onto the wound. Then Hydrogel is applied on top of the ointment. Apply tincture of benzoin to the surrounding skin, followed with an application of Leukotape.
The blisters are occurring because there is shear force friction which needs to be minimized or eliminated. As mentioned above, pre-taping likely areas that could blister is one strategy. Applying Bodyglide, or Hiker's Goo, or even vaseline can also help. I will wear one pair of thin padded wool socks that are almost tight on the foot and keep my shoes a bit loose so that the shear force happens between the sock and the shoe. When shoes are tied too tight, the shear force can take place between the skin of the foot and the sock.
When going downhill, I will temporarily tighten up the shoe to keep my toes from banging on the front of the shoe, which creates its own separate problem. I am also very watchful for any hint of a hotspot which might require immediate attention.